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Research Highlights

Dendrimer Mediated Drug Delivery & Targeting

Dendrimers are hyper-branched, mono-dispersed, three-dimensional macro-molecules of nanometric size. PAMAM dendrimers are the most explored and potential dendrimeric nanocarriers for effective drug delivery in the management of diseases such as Cancers, glioblastoma and Alzheimer's disease etc. Few recent research publications addressing these diseases are:

Alzheimer's Disease

  • Vitamin-C Decorated PEGylated PAMAM Dendrimers for Effective Inhibition of Amyloid Aggregation and Improved In vivo Pharmacokinetics. Journal of Drug Delivery Science and Technology. 2023; 89(105058): 01-17. 

  • Lactoferrin Coupled Lower Generation PAMAM Dendrimers for Brain Targeted Delivery of Memantine in Aluminum-Chloride-Induced Alzheimer’s Disease in Mice. Bioconjugate Chemistry. 2019;30(10):2573-2583. 

  • Behavioral and Biochemical Implications of Dendrimeric Rivastigmine in Memory-Deficit and Alzheimer’s Induced Rodents. ACS Chemical Neuroscience. 2019;10(8):3789-3795. 

  • Dendrimer Donepezil Conjugates for Improved Brain Delivery and Better in Vivo Pharmacokinetics. ACS Omega. 2019;4(3):4519−4529. 

  • Boosted Memory and Improved Brain Bio-availability of Rivastigmine: Targeting Effort to Brain using Covalently Tethered Lower Generation PAMAM Dendrimers with Lactoferrin. Molecular Pharmaceutics. 2018;15(10):4538-4549. 

Glioblastoma Multiforme

  • Angiopep-2 Grafted PAMAM Dendrimers for the Targeted Delivery of Temozolomide: In-vitro and In-vivo Effects of PEGylation in the Management of Glioblastoma Multiforme. ACS Biomaterials Science & Engineering. 2023; 9(7): 4288–4301. 

  • Chitosan Engineered PAMAM Dendrimers as Nanoconstructs for the Enhanced Anti-cancer Potential and Improved in vivo Brain Pharmacokinetics of Temozolomide. Pharmaceutical Research. 2018;35(9):01-14.

Cancer

  • Lipid-Dendrimer Nanohybrid System or Dendrosomes: Evidences of Enhanced Encapsulation, Solubilization, Cellular Uptake and Cytotoxicity of Bortezomib. Applied Nanoscience. 2020;10:4049-4062.

  • PEGylated Dendrimer Mediated Delivery of Bortezomib: Drug Conjugation versus Encapsulation. International Journal of Pharmaceutics. 2020;584:11938.

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Polymeric Nanoconjugates in Drug Targeting

Polymeric nanoconjugates have proven to be a potential candidate for drug delivery in managing breast cancer.

  • Sialic Acid Engineered Prodrug Nanoparticles for Co-delivery of Bortezomib and Selenium in Tumor Bearing Mice. Bioconjugate Chemistry. 2023; 34(9): 1528–1552. 

  • Biodegradable Nanoparticulate Co-Delivery of Flavonoid and Doxorubicin: Mechanistic Exploration and Evaluation of Anticancer Effect In Vitro and In Vivo. Biomaterials and Biosystems. 2021; 3(100022):01-15. 

  • Doxorubicin and Crocin Co-delivery by Polymeric Nanoparticles for Enhanced Anticancer Potential In Vitro and In Vivo. ACS Applied Bio Materials. 2020;3(11):7789-7799. 

  • HPMA-PCL Polymeric Micelles in Co-delivery of Proteasome Inhibitor and Polyphenol: Exploration of Synergism or Antagonism. Molecular Pharmaceutics. 2023; 20(1): 524–544. 

  • Sialic Acid Conjugated Chitosan Nanoparticles: Modulation to Target Tumour Cells and Therapeutic Opportunities AAPS PharmSciTech. 2022; 23(10):01-16. ​

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Research Grants

  • DBT Research Grant: Development of novel formulation for prevention and control of teat and udder infection in cattle, 2023-2026, 53.74 Lacs INR (Co-PI) 

  • DST Indo-Belarus Research Grant: Exploration of aptamer Gint4.T based dendrimeric carrier for the brain delivery of anticancer drug temozolomide, 2023-2025, 8.3 Lacs INR (PI)

  • DST-SERB Research Grant: Design, synthesis and characterization of multifunctional platform for targeted tumor phototherapy, 2018-2022, Rs. 60.9 Lacs INR (Co-PI)

  • Rajasthan DST Research Grant: Dendrimer mediated non-invasive delivery of Rifampicin and Imipenem for the effective treatment of pulmonary tuberculosis, 2016-2021, 3.06 Lacs INR (PI)  

  • DST-SERB Research Grant: Multifunctional nanotherapeutics for the effective treatment of advanced breast cancer: A dual drug delivery approach for siRNA and anti-cancer drug, 2015-2018, 28.54 Lacs INR (PI)  

  • UGC-BSR Research Start-up Grant: Evaluation of PAMAM dendrimers to deliver drugs bypassing blood brain barrier through nasal route, 2014-2017, 6 Lacs INR (PI)

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